Which two cytokines are the main stimuli for B cell differentiation into plasma cells?
A) TNF and IL-1
B) TACI and BLyS
C) BLyS and APRIL
D) TLR-4 and Lipid A

Question

Quizplus · Accepted Answer

B lymphocyte stimulator (BLyS) and APRIL are cytokines that bind to their respective receptors to activate B cell proliferation, differentiation, and antibody class switching. TNF and IL-1 are produced by macrophages at the site of infection during the inflammatory response. TACI is one of the receptors for BLyS. Lipid A is a bacterial component that binds to TLR4, leading to B cell stimulation; neither are cytokines.

Which Two Cytokines Are the Main Stimuli for B Cell