The main immune response in a case of acute rejection of a transplanted organ is:
A) B cell activation
B) Both B and T cell activation
C) Allospecific T cell activation
D) Attack of organ by pre-existing antibodies

Question

Quizplus · Accepted Answer

Hyperacute rejection is mediated by pre-existing antibodies to donor antigens, such as HLA or ABO antigens, and begins immediately after the graft is attached to the recipient. Acute rejection is mediated by allospecific T cells. Passenger leukocytes, which are donor dendritic cells, travel to the lymph nodes and activate recipient T cells, leading to an immune response that damages the grafted organ. Chronic rejection occurs after months or years and involves both B and T cell responses. Thickening of the vascular intima, along with smooth muscle proliferation, can lead to blockage of vessels and ischemia of the transplanted organ.

The Main Immune Response in a Case of Acute Rejection