Which immunosuppressive agent causes redistribution of CD4 T cells from the peripheral blood to the spleen and bone marrow?
A) Corticosteroids
B) Monomurab-CD3
C) Calcineurin inhibitors
D) Antiproliferative agents

Question

Quizplus · Accepted Answer

Corticosteroids have a variety of effects on the immune system, one of which is to cause CD4 T cells to move out of the peripheral blood and into the spleen and bone marrow. T cell proliferation and B cell maturation are also reduced by corticosteroids. The calcineurin inhibitors block interleukin-2 (IL-2) synthesis, which blocks T cell stimulation. The antiproliferative agents block proliferation of T and B cells. Monomurab-CD3 is a monoclonal antibody that inhibits T cell activation.

Which Immunosuppressive Agent Causes Redistribution of CD4 T Cells from the Peripheral