How does the "hole in the T cell repertoire" model explain why some individuals may fail to respond to an antigen?
A) MHC class II molecules differ in their ability to bind and process antigen.
B) The TCR is lacking appropriate accessory molecules to fully transduce signals.
C) Some individuals lack a lymphocyte with a TCR that recognizes a specific antigen.
D) Antigen is inappropriately presented on MHC class I molecules rather than class II molecules.

Question

Quizplus · Accepted Answer

The "hole in the T cell repertoire" model proposes that some individuals may lack a lymphocyte with a TCR that recognizes a specific antigen. The "determinant selection" model proposes that MHC class II molecules differ in their ability to bind and process antigen. Either or both may explain why some individuals may fail to respond to some antigens.

How Does the "Hole in the T Cell Repertoire" Model