Which of the Following Questions Is/are Important When Critically Appraising

Which of the following questions is/are important when critically appraising a study that purports to test the effectiveness of an intervention, program, or policy?

A) From a logical standpoint, was the intervention, program, or policy the most plausible cause of the observed outcome, or is some alternative explanation also quite plausible?
B) Was outcome measured in a valid and unbiased manner?
C) What is the probability that the apparent effectiveness, or lack thereof, can be attributed to statistical chance?
D) Do the study participants, intervention procedures and results seem applicable to your practice context?
E) All of the above.