Concerning the Two Immunofluorescence Methods of Diagnosing Viral Infection, Which

Concerning the two immunofluorescence methods of diagnosing viral infection, which statement is correct?

A) Direct immunofluorescence is generally more rapid and specific than indirect immunofluorescence.
B) Indirect immunofluorescence is best suited to situations in which large quantities of virus are suspected.
C) Signal amplification of the direct test decreases specificity by increasing nonspecific background fluorescence.
D) High-quality monoclonal antibodies improve the sensitivity and specificity of the direct test.
E) All of the above are correct.