Which tissues are most commonly affected by mutation of the CFTR gene?

Question

Quizplus · Accepted Answer

The two main organ systems affected involve epithelial cells and are the lungs and the pancreas. The epithelial cells in these tissues produce a thick, sticky mucus as a result of poor chloride transport that, over time, plugs up the glands in these organs, causing glandular atrophy and organ dysfunction or failure. Other organs that are affected to a far lesser degree include the liver, salivary glands, and testes.

Which Tissues Are Most Commonly Affected by Mutation of the CFTR