What do the known monogenic disorders that result in the expression of hypertension have in common?
A)An error in the ability of vascular smooth muscle to contract
B)An error in the ability of vascular smooth muscle to relax
C)Excessive kidney reabsorption of sodium
D)Excessive kidney excretion of potassium

Question

Quizplus · Accepted Answer

Most of the monogenic disorders that result in the expression of hypertension affect the way the kidneys control salt, causing it to be reabsorbed and retained instead of excreted. When salt is retained, excess fluid is not excreted, which leads to hypertension. The genes involved are usually part of complex pathways, such as the renin-angiotensin-aldosterone (RAAS) pathway, although other hormonal imbalances may also be involved. Potassium is excreted in most of these disorders, but potassium loss does not cause hypertension. Vascular smooth muscle constriction and the inability of this tissue to relax do increase peripheral resistance, which can lead to hypertension, but this pathogenesis is not part of most hypertension-associated monogenic disorders.

What Do the Known Monogenic Disorders That Result in the Expression