Why are single-nucleotide polymorphisms (SNPs), which have been associated with schizophrenia and bipolar disorder, currently not used to diagnose either of these disorders?

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Schizophrenia, bipolar disorder, and nicotine dependence have been found to have single-nucleotide polymorphisms (SNPs) that alter a single DNA base. However, so far, these SNPs have not been shown to be significant enough to bring about a psychiatric disorder. Instead, they increase or decrease the risk by a small fraction, much less than twofold, so testing one of these does not warrant developing it as a diagnostic test. SNPs do cause a point mutation and can cause a frameshift mutation. At this time, no gene changes in psychiatric or behavioral disorders can be altered by pharmacologic therapy.

Why Are Single-Nucleotide Polymorphisms (SNPs), Which Have Been Associated with Schizophrenia