Which amino acid is least likely to participate in acid-base catalysis?
A)Lysine.
B)Valine.
C)Aspartate.
D)Histidine.

Question

Quizplus · Accepted Answer

Acid-base catalysis requires the presence of a protonated or deprotonated functional group that can act as an acid or base. Lysine and Aspartate both have functional groups that can be protonated or deprotonated, making them more likely to participate in acid-base catalysis. Histidine is also a good candidate for acid-base catalysis, as its imidazole side chain can easily donate or accept protons. Valine, however, has a nonpolar side chain that cannot participate in acid-base catalysis.

Which Amino Acid Is Least Likely to Participate in Acid-Base