When the concentration of a substrate inside a cell falls below the substrate concentration at half maximal velocity,________.
A)ES is formed more easily
B)ES dissociates to E + S
C)ES is closer to the ground state than to the transition state
D)E + S is in equilibrium with ES
E)the reaction will not proceed

Question

Quizplus · Accepted Answer

When the substrate concentration falls below the concentration at half maximal velocity, there are fewer substrate molecules available to bind with the enzyme's active site. As a result, some of the ES complexes dissociate to regenerate the E and S molecules. This is known as substrate inhibition.

When the Concentration of a Substrate Inside a Cell Falls