Zymogens are inactive enzyme precursors which are made active by
A)a change in folding only.
B)selective proteolysis.
C)methylation of particular residues.
D)a change in pH.

Question

Quizplus · Accepted Answer

Zymogens are activated by selective proteolytic cleavage, which removes a specific peptide portion or domain, thereby inducing a conformational change in the protein and exposing the active site for enzymatic activity. This prevents the enzyme from being prematurely activated and causing damage to cells and tissues. Other choices such as changes in folding, methylation, and pH are not primary mechanisms for zymogen activation.

Zymogens Are Inactive Enzyme Precursors Which Are Made Active by