Use the Following to Answer the Following Questions -Recent Evidence Shows That the Extracellular Matrix Can Take Part

Use the following to answer the following questions. All three are involved in maintenance of cell shape.
$\begin{array}{c}\begin{array}{|l}\hline\\ \text {Property}\\\hline\\\\ \text {Structure}\\\hline\\ \text {Diameter}\\\hline \text {Main}\\\text {functions}\\\hline \end{array}\begin{array}{|l|}\hline \text { Microtubules (tubulin}\\\text { polymers) }\\\hline \text {Hollow tubes; wall}\\ \text {consists of 13 columns}\\ \text {of tubulin molecules}\\\hline \text {\( 25 \mathrm{~nm} \) with 15-nm}\\ \text {lumen}\\\hline\\ \text {Cell motility}\\\hline \end{array}\begin{array}{l|}\hline \text { Microfilaments (actin}\\ \text { filaments) }\\\hline \text { Two intertwined strands}\\ \text { of actin, each a polymer }\\ \text { of actin subunits}\\\hline\\ \text { \( 7 \mathrm{~nm} \) }\\\hline\\ \text { Cell motility}\\\hline \end{array}\begin{array}{l|}\hline \text {Intermediate}\\ \text {filaments}\\\hline \text {Fibrous proteins }\\ \text {supercoiled into}\\ \text { thicker cables}\\\hline\\ \text {8-12nm}\\\hline\\ \text {Anchorage}\\\hline\end{array}\end{array}$

-Recent evidence shows that the extracellular matrix can take part in regulating the expression of genes. A likely possibility for this might be which of the following?

A) Mechanical signals of the ECM can alter the cytoskeleton, which can alter intracellular signaling.
B) Intracellular signals might cause changes in the fibronectin binding to the cell surface.
C) Orientation of microfilaments to the ECM can change the gene activity.
D) Fibronectin binds to integrins built into the plasma membrane.
E) Proteoglycans in the ECM become large enough in aggregate to force genetic alteration.