Rank the following 1-base point mutations (from most likely to least likely)with respect to their likelihood of affecting the structure of the corresponding polypeptide: 1. insertion mutation deep within an intron
2) substitution mutation at the 3rd position of an exonic codon
3) substitution mutation at the 2nd position of an exonic codon
4) deletion mutation within the first exon of the gene

Question

Quizplus · Accepted Answer

A deletion mutation within the first exon (4) is most likely to affect the polypeptide structure as it can cause a frameshift. A substitution at the 2nd position (3) often changes the amino acid, affecting the protein. A substitution at the 3rd position (2) may be silent due to codon redundancy. An insertion within an intron (1) is least likely to affect the polypeptide as introns are non-coding regions.

Rank the Following 1-Base Point Mutations (From Most Likely to Least