Use the Following Information to Answer the Questions Below

Use the following information to answer the questions below.
HIV's genome of RNA includes code for reverse transcriptase (RT) , an enzyme that acts early in infection to synthesize a DNA genome off of an RNA template. The HIV genome also codes for protease (PR) , an enzyme that acts later in infection by cutting long viral polyproteins into smaller, functional proteins. Both RT and PR represent potential targets for antiretroviral drugs. Drugs called nucleoside analogs (NA) act against RT, whereas drugs called protease inhibitors (PI) act against PR.
-Which is a True statement concerning genetic variation?

A) It is created by the direct action of natural selection.
B) It arises in response to changes in the environment.
C) It must be present in a population before natural selection can act upon the population.
D) It tends to be reduced by the processes involved when diploid organisms produce gametes.
E) A population that has a higher average heterozygosity has less genetic variation than one with a larger average heterozygosity.