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A large population of laboratory animals has been allowed to breed randomly for a number of generations. After several generations, 25% of the animals display a recessive trait (aa), the same percentage as at the beginning of the breeding program. The rest of the animals show the dominant phenotype, with heterozygotes indistinguishable from the homozygous dominants.
-What is the estimated frequency of allele A in the gene pool?

Question

Quizplus · Accepted Answer

Since the recessive trait is only present in individuals with the genotype aa, and they make up 25% of the population, the frequency of the aa genotype is 0.25. This can be written as q^2, where q is the frequency of the recessive allele a. Solving for q gives a frequency of 0.5. Since there are only two alleles in the gene pool (A and a) and their frequencies must add up to 1, the frequency of A is 1 - q, which is also 0.5. Therefore, the estimated frequency of allele A in the gene pool is 0.50.

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