How does tissue damage occur in acute rejection after an organ transplant?
A)Th1 cells release cytokines that activate infiltrating macrophages and cytotoxic T cells directly attack the endothelial cells of the transplanted tissue.
B)Circulating immune complexes are deposited in the endothelial cells of transplanted tissue, where the complement cascade lyses tissue.
C)Antigens on the cell surface of transplanted tissue are recognized by receptors on NK cells, which release lysosomal enzymes that destroy tissue.
D)Antibodies coat the surface of transplanted tissue to which mast cells bind and liberate preformed chemical mediators that destroy tissue.

Question

Quizplus · Accepted Answer

Sensitization is usually initiated by the recipient's lymphocytes interacting with the donor's dendritic cells within the transplanted tissue, resulting in induction of recipient Th1 and Tc cells against the donor's antigens. The Th1 cells release cytokines that activate infiltrating macrophages, and the Tc cells directly attack the endothelial cells in the transplanted tissue.

How Does Tissue Damage Occur in Acute Rejection After an Organ