In DIC, what activates the coagulation cascade?
A)Cytokines, such as platelet-activating factor (PAF), and tumor necrosis factor- alpha (TNF-a)
B)Thromboxane A causing platelets to aggregate and consume clotting factors
C)Tissue factor (TF) located in the endothelial layer of blood vessels and subcutaneous tissue
D)Endotoxins from gram-negative and gram-positive bacteria circulating within the bloodstream

Question

Quizplus · Accepted Answer

Direct tissue damage (ischemia and necrosis, surgical manipulation, crushing injury) also result in release of tissue factor (TF) by the endothelium. The common pathway for DIC appears to be excessive and widespread exposure of TF.

In DIC, What Activates the Coagulation Cascade