Which proinflammatory cytokines are responsible for the development and maintenance of DIC?
A)Granulocyte colony-stimulating factor (G-CSF); IL-2, IL-4, and IL-10; and IFN-g
B)Granulocyte-macrophage colony-stimulating factor (GM-CSF); IL-3, IL-5, and IL-9, and IFN-g
C)Macrophage colony-stimulating factor (M-CSF); IL-7, IL-11, and IL-14; and PAF
D)TNF-a; IL-1, IL-6, and IL-8; and PAF

Question

Quizplus · Accepted Answer

Endotoxin, in particular, triggers the release of multiple cytokines that play a significant role in the development and maintenance of DIC. Proinflammatory cytokines (TNF-a; IL-1, IL-6, IL-8; and PAF) are responsible for the clinical signs and symptoms associated with sepsis.

Which Proinflammatory Cytokines Are Responsible for the Development and Maintenance