How does a plasma membrane protein become imbedded in the membrane?
A)Ribosomes attach to the plasma membrane and translation of the peptide occurs directly on the PM.
B)Ribosomes enter the endoplasmic reticulum and make the proteins within the ER.
C)Once the signal peptide is translated, the ribosome complex is escorted to the PM, translation continues and the peptide is inserted through a pore in the membrane.
D)Once the signal peptide is translated, the ribosome complex is escorted to the ER, translation continues and the peptide is inserted through a pore in the membrane.
E)Once completed, the protein is escorted to the PM and a chaperone protein pushes it in.

Question

Quizplus · Accepted Answer

Plasma membrane proteins are typically synthesized on ribosomes bound to the endoplasmic reticulum (ER). Once the signal peptide is translated, the ribosome complex is escorted to the ER membrane, where the protein is inserted through a pore in the membrane. The protein is then transported to the plasma membrane via vesicular transport.

How Does a Plasma Membrane Protein Become Imbedded in the Membrane