The physiological buffers serve as a secondary defense against harmful shifts in the pH of body fluids.

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Physiological buffers, such as bicarbonate and protein buffers, work to maintain a stable pH in the body by donating or accepting hydrogen ions. They are considered a secondary defense, with the first line of defense being chemical buffers and the third line of defense being respiratory and renal mechanisms.

The Physiological Buffers Serve as a Secondary Defense Against Harmful