The Transition of Opiate Use from an Acceptable,if Often Abused,pain

The transition of opiate use from an acceptable,if often abused,pain reliever to that of a pleasure-seeking drug also saw a change in __________.

A) the drug's pharmacology,which provided more relief for the "psychological pain" of poverty and urban life
B) the distribution from doctors to pushers
C) the demographics of the user to that of working-class males,increasingly "of colour"
D) its former female demographic,which turned increasingly to social drinking during the Roaring Twenties