In Sickle Cell Anemia, the Replacement of Glutamate by Valine

In sickle cell anemia, the replacement of glutamate by valine in position 6 of the β chain leads to serious trouble.Which of the following amino acid changes at position 6 would cause only a minimal change in the properties of hemoglobin?

A) Glutamate to aspartate.
B) Glutamate to proline.
C) Glutamate to isoleucine.
D) Glutamate to methionine.
E) Glutamate to tryptophan.