A Type of Somatic Mutation That Inhibits Apoptosis and Thereby

A type of somatic mutation that inhibits apoptosis and thereby permits the survival of deviant cells is:

A) Loss of the gene for Akt (protein kinase B) .
B) Amplification of the retinoblastoma gene.
C) Loss of the gene for PTEN, the lipid phosphatase that destroys phosphatidylinositol-3,4,5-trisphosphate.
D) Loss of the gene for the p53-binding protein Mdm2.
E) Amplification of the gene for E2F.