Glucokinase Is Used by Liver and Pancreatic B Cells to Adjust

Glucokinase is used by liver and pancreatic b cells to adjust glucose metabolism to changing levels of blood glucose.This is possible because there is an important difference between glucokinase and the other isoforms of hexokinase:

A) Glucokinase uses ATP as a substrate, but hexokinase does not.
B) Glucokinase has a higher Km value for glucose than does hexokinase.
C) Glucokinase has a maximal reaction rate (Vmax) that changes with the blood glucose concentration.
D) Glucokinase uses both glucose and fructose as substrates, whereas the other forms of hexokinase can use only glucose.
E) Glucokinase is located on the cell surface, whereas the other forms of hexokinase are cytoplasmic.