Exposure to radiation would lead to activation of which caspase pathway?
A) Extrinsic pathway
B) Intrinsic pathway
C) Common pathway
D) None of the above

Question

Quizplus · Accepted Answer

Exposure to radiation would lead to activation of the intrinsic pathway of apoptosis, also known as the mitochondrial pathway. Radiation induces DNA damage which in turn leads to mitochondrial damage and release of cytochrome c, activating caspases in the cytosol to initiate the apoptotic pathway. The extrinsic pathway is activated by extracellular signals such as cytokines or death ligands and the common pathway involves the activation of effector caspases like caspase-3.

Exposure to Radiation Would Lead to Activation of Which Caspase