Which two proteins are critical for the effective function of the G₁ checkpoint?
A)Cdk4 and Cdk6
B)Cyclin E
C)P21 and p57
D)P53 and Rb

Question

Quizplus · Accepted Answer

The G₁ checkpoint is regulated by the tumor suppressor protein p53 and the retinoblastoma protein (Rb). These proteins inhibit the activity of cyclin-dependent kinases (Cdks) and prevent progression through the cell cycle until DNA damage is repaired or other conditions are met. Therefore, the correct answer is D - P53 and Rb.

Which Two Proteins Are Critical for the Effective Function of the G₁