Question 1

Describe the dopamine theory of addiction.What is the current status? Be sure to support your conclusions with experimental results.

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Question 2

Make three reasonable recommendations for improving the ways in which your country deals with the drug addiction problem.Base your recommendations on relevant research findings and logical arguments.

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Question 3

Define the intracranial self-stimulation phenomenon.Describe and discuss three of its major characteristics.What effect has research on this phenomenon had on the study of the neural mechanisms of drug addiction?

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Question 4

If you wanted to conduct a study to determine whether rats find a particular drug pleasurable, the conditioned __________ paradigm would be a good test to use.

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Question 5

Discuss the relationships among tolerance, withdrawal symptoms, addiction, and physical dependence.

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Question 6

Describe the physical-dependence and positive-incentive perspectives of addiction.What is the current status of the "debate" between these two perspectives.How well does each account for relapse?.

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Question 7

As drug addiction develops, the control of drug taking seems to spread from the ventral to the dorsal __________.

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Question 8

Which system is illustrated here? What is thought to be its function? This system is believed to be composed of two separate pathways: Name them and discuss.Label each of the 9 indicated structures using each of these 9 terms: prefrontal cortex, dorsal striatum, substantia nigra, amygdala, nucleus accumbens, limbic cortex, ventral tegmental area, septum, and olfactory tubercle.

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Question 9

Compare the hazards of one legal and one illegal addictive drug.What does your comparison suggest?

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Question 10

Discuss contingent and conditioned drug tolerance.Explain the significance of these phenomena, and describe one experimental demonstration of each.

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Question 11

The dopaminergic brain nucleus that has been linked more than any other to the rewarding effects of addictive drugs is the nucleus __________.

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Question 12

Recent research suggests that dopamine release in the nucleus accumbens may be related more to the __________ of reward than to the experience of the reward.

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Question 13

Dopamine __________ are molecules in the presynaptic membrane of dopaminergic neurons that mediate the re-uptake of dopamine from the synapse.

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Quiz 15: Drug Addiction and the Brains Reward Circuits