Shh signaling is important for the development of the skin and many of its appendages.What is the main cellular mechanism by which Shh controls development of the ectodermal appendages?

Question

Quizplus · Accepted Answer

Shh signaling is primarily involved in promoting cell proliferation during the development of ectodermal appendages such as hair, feathers, and nails. In the absence of Shh signaling, these structures do not develop properly, leading to defects in skin and hair growth. While Shh may also have some role in promoting cell survival and adhesion, its primary function in this context is proliferation.

Shh Signaling Is Important for the Development of the Skin