Which signaling factor is essential for patterning of the limb across the cranial-caudal axis?

Name: Which signaling factor is essential for patterning of the limb across the cranial-caudal axis?
Brand: Quizplus
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Question

Quizplus · Accepted Answer

Shh is essential for patterning of the limb across the cranial-caudal axis. It is expressed in the zone of polarizing activity (ZPA) at the posterior margin of the limb bud and acts in a concentration-dependent manner to specify identity along the anterior-posterior axis.

Which Signaling Factor Is Essential for Patterning of the Limb