Which one of the following statements about MHC-TCR interactions is NOT true?
A)Antigen receptors on T cells bind to MHC molecules for only brief periods of time.
B)The affinity of most TCRs for peptide-MHC complexes is similar to the affinity of antibodies for their antigens.
C)Only 1% or less of the MHC molecules on any antigen-presenting cell (APC)display a peptide recognized by a particular T cell.
D)T cells usually require multiple engagements with an APC before a threshold of activation is reacheD.
E)A subthreshold number of MHC-TCR interactions can lead to T cell inactivation.

Question

Quizplus · Accepted Answer

In general,the TCR binds to peptide-MHC complexes with lower affinity than antigen-antibody interactions.This relatively low-affinity interaction occurs briefly;thus,a T cell may need multiple engagements with the antigen-presenting cell (APC)before a threshold of activation occurs.If this threshold is not reached,the T cell may enter into an inactive state known as anergy.On any given APC,less than 1% of the MHC molecules display the same peptide.

Which One of the Following Statements About MHC-TCR Interactions Is