Which of the following would NOT be a likely therapy for treating autoimmune diseases?
A)Corticosteroids
B)Small molecule inhibitor of VLA-4
C)Cyclosporine
D)CTLA-4 antagonist
E)Plasmapheresis

Question

Quizplus · Accepted Answer

The mainstay therapy for hypersensitivity diseases is anti-inflammatory drugs,particularly corticosteroids.In contrast,blocking CTLA-4,a negative regulator of T cell responses,is likely to exacerbate preexisting conditions of hypersensitivity.(The CTLA-4 knockout mouse displays a lymphoproliferative phenotype. )An inhibitor of VLA-4 would be effective in blocking leukocyte transmigration into tissues,thus exerting an anti-inflammatory effect.Cyclosporine is a potent immunosuppressive drug used to block T cell activation.Plasmapheresis has been used during exacerbations of antibody-mediated diseases to reduce circulating levels of antibodies or immune complexes.

Which of the Following Would NOT Be a Likely Therapy