Which One of the Following Statements Concerning Autoimmune Disease Is

Which one of the following statements concerning autoimmune disease is true?

A) Autoimmunity manifests as organ-specific,not systemic,disease.
B) Infectious microorganisms are frequently present in autoimmune lesions.
C) Effector mechanisms in autoimmunity include circulating autoantibodies,immune complexes,and autoreactive T lymphocytes.
D) Among the genes associated with autoimmunity,associations are particularly prevalent with class I MHC genes.
E) Many autoimmune diseases show higher incidence in males than in females.