A 7-month-old boy is evaluated in the clinic for recurrent bacterial infections.His tonsils are not visible on physical examination.Serum immunoglobulin A (IgA)and IgG levels are markedly decreased,and serum IgM levels are slightly below normal.Based on this family's history and clinical presentation,a mutation in which of the following genes is most likely to be found in this patient?

Question

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X-linked severe combined immunodeficiency disease (SCID)results from mutations in the gene encoding the cytokine receptor common F1F1F1S1?F1F1F10 chain.Mutations in any of the other genes listed (JAK3 kinase,adenosine deaminase,RAG2,or purine nucleoside phosphorylase)cause severe combined immunodeficiency syndrome with autosomal recessive patterns of inheritance.

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