All of the following have a direct role in mediating human immunodeficiency virus (HIV)entry into susceptible cells EXCEPT:

Question

Quizplus · Accepted Answer

Human immunodeficiency virus (HIV)entry into host cells occurs when gp120,a glycoprotein expressed on the HIV envelope,binds to CD4 expressed on host T cells.This induces a conformational change in gp120,promoting its binding to a chemokine coreceptor,such as CCR5 or CXCR4,on host cells.A conformational change in gp41,another glycoprotein expressed on the HIV envelope,exposes a fusion peptide,which inserts into the T cell membrane,allowing fusion of viral and cell membranes and subsequent infection of the host cell.Thus,CD4,CCR5,and CXCR4 are host proteins that are directly involved in mediating HIV entry into susceptible T cells,macro-phages,and dendritic cells.Env,the HIV envelope glycoprotein that includes gp120 and gp41,is also directly involved in mediating HIV entry into host cells.In contrast,MHC class I molecules do not have a direct role in this process.

All of the Following Have a Direct Role in Mediating