Which of the following factors may have an effect on drug absorption?
1)Route of administration
2)Metabolic degradation
3)Inactivation by stomach acids
4)Blood flow to absorption site

Question

Quizplus · Accepted Answer

The route of administration determines which barriers to absorption must be crossed by a drug.Such barriers can affect the drug's time to onset and time to peak effect.Intravenous administration bypasses the need for absorption from the gastrointestinal tract seen with oral administration,generally gives a very rapid onset and peak effect,and provides 100% availability of the drug in the bloodstream.The amount of drug in the bloodstream (its bioavailability)is influenced not only by absorption but also by inactivation caused by stomach acids and by metabolic degradation,which can occur before the drug reaches the main systemic compartment.Another important variable governing absorption and bioavailability is blood flow to the site of absorption.

Which of the Following Factors May Have an Effect on Drug