The antiinflammatory effects of theophylline include which of the following?
1)Decreased migration of activated eosinophils into bronchial mucosa
2)Increased T-cell proliferation and accumulation in atopic asthma
3)Inhibition of proinflammatory cytokines
4)Reduced airway responsiveness to stimuli such as histamine and methacholine

Question

Quizplus · Accepted Answer

Theophylline has antiinflammatory effects,which may help explain its efficacy despite the fact that the drug is a relatively weak bronchodilator.Antiinflammatory effects include decreased migration of activated eosinophils into bronchial mucosa with allergen stimuli and reduced eosinophil survival;reduced T-cell proliferation and accumulation in atopic asthma with corresponding improvement in pulmonary function;inhibition of proinflammatory cytokines,such as interleukin (IL)-1F1F1F1S1F1F1F10,tumor necrosis factor-F1F1F1S1F1F1F10,and interferon-F1F1F1S1F1F1F10,and increased production of the antiinflammatory cytokine IL-10;attenuation of the late-phase response to histamine in patients with allergic asthma;reduced airway responsiveness to stimuli such as histamine,methacholine,allergen,sulfur dioxide,distilled water,cyanates,and adenosine;and increased activation of a group of enzymes,histone deacetylase,also known as lysine deacetylase,which are used by corticosteroids to reduce inflammatory response.

The Antiinflammatory Effects of Theophylline Include Which of the Following