Nitric oxide (NO)is a

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NO is a product of endothelial cells that acts as a nitrovasodilator.Because NO diffuses so readily into the bloodstream and is inactivated by being bound to hemoglobin,its action is limited to the pulmonary vascular endothelium,whether generated endogenously within the lung or inhaled as an exogenous gas.It is a selective pulmonary vasodilator.NO was investigated for its ability to reduce pulmonary vascular resistance in various disease states,such as persistent pulmonary hypertension of the newborn (PPHN)and acute respiratory distress syndrome (ARDS).NO is approved for use in neonates with hypoxic respiratory failure,to reduce pulmonary artery pressure,and to increase oxygenation in newborns with pulmonary hypertension and hypoxia.

Nitric Oxide (NO)is a