The recommended dose of nitric oxide (NO)is

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NO,supplied in two sizes of gas cylinder,is available at 100 ppm and 800 ppm.The recommended dose is 20 ppm.The treatment should be maintained up to 14 days,or until the underlying oxygenation problem has resolved and the neonate can be successfully weaned from NO.In the Neonatal Inhaled Nitric Oxide Study (NINOS),most patients who failed to improve on 20 ppm and whose dose was increased to 80 ppm had no response at the higher concentration.The risk of methemoglobinemia and elevated nitrogen dioxide (NO₂)levels increases significantly at doses greater than 20 ppm.

The Recommended Dose of Nitric Oxide (NO)is