Most cases of depression are believed to be caused by

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Depressive disorder has multiple etiologies,including biologic,psychological,and social factors.Serotonin and norepinephrine have been shown to be important neurotransmitters,and their relative deficiency has been linked to depression.For more than a decade,the first-line medical treatment for major depressive disorder has been selective serotonin reuptake inhibitors (SSRIs).These drugs are preferred because they are safer and more tolerable than the older medications,such as tricyclic antidepressants and monoamine oxidase inhibitors.In addition,newer drugs target both norepinephrine and serotonin.They are called serotonin norepinephrine reuptake inhibitors.

Most Cases of Depression Are Believed to Be Caused by