Major problems with the administration of NSAIDs are

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Gastric irritation and ulceration are major problems with administering NSAIDs.Renal injury can result from prolonged use and high dosages of these medications.NSAIDs also inhibit platelet aggregation,and this compounds the problem of gastrointestinal bleeding.The antiplatelet effects are used therapeutically either after or to prevent cardiac thrombosis.Aspirin use in childhood febrile illness has been associated with an increased incidence of Reye syndrome,an often fatal increase in intracranial pressure associated with massive hepatic dysfunction.Allergic reactions to this class of drugs are common.Rashes,urticaria,angioneurotic edema,asthma,and anaphylaxis have been seen.

Major Problems with the Administration of NSAIDs Are