The factor that MOST affects the thermostability of a protein is its
A) highly hydrophobic core regions.
B) folding pattern.
C) ionic surface interactions.
D) number of hydrogen bonds.

Question

Quizplus · Accepted Answer

The folding pattern of a protein, which determines its overall three-dimensional structure, is the primary factor that affects its thermostability. Incorrect folding or unfolding can result in the exposure of hydrophobic regions that would typically be buried, leading to protein aggregation and a loss of function. Additionally, stable hydrogen bonds and ionic interactions can help maintain protein structure, but the folding pattern is crucial for overall thermostability.

The Factor That MOST Affects the Thermostability of a Protein