The presence of which of the following in the bone marrow would lead the clinician to a diagnosis of a myeloproliferative disorder rather than of an acute leukemia?

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Myeloproliferative disorders are characterized by the overproduction of mature blood cells in the bone marrow, leading to high numbers of proliferating mature cells. In contrast, acute leukemias are characterized by the overproduction of immature, young dividing cells. High amounts of bone marrow fat present are a normal finding in healthy individuals, and high amounts of abnormal cells suggest malignant transformation, which could be present in both myeloproliferative disorders and acute leukemias.

The Presence of Which of the Following in the Bone