Interpret the following results: -WBC count: 102 x 109/L
-Differential: 13% segmented neutrophils, 28% band neutrophils, 15% metamyelocytes, 8% myelocytes, 6% promyelocytes, 15% lymphocytes, 8% basophils, 7% monocytes
-LAP score: 100 band and segmented neutrophils:
-Cells with a negative (0) reaction = 92
-Cells with a positive 1+ reaction = 5
-Cells with a positive 2+ reaction = 3
What is the LAP score? What disease is associated with this LAP score?

Question

Quizplus · Accepted Answer

The LAP score is calculated by counting the number of cells with positive staining for leukocyte alkaline phosphatase (LAP) and subtracting it from the total number of neutrophils. A high LAP score (over 100) is associated with chronic myelogenous leukemia (CML), while a low LAP score is indicative of leukemoid reaction. In this case, the LAP score is 11, which is within the normal range, and therefore, no disease association can be made. The WBC count is elevated, but the differential count shows no significant abnormality.

Interpret the Following Results: -WBC Count: 102 X 109/L