What cell appears to be the primary site for the defect in MPD?

Question

Quizplus · Accepted Answer

MPD (Myeloproliferative Disorders) is a group of disorders that involve the overproduction of one or more blood cell types. The primary site of the defect is in the Hematopoietic Stem Cells (HSCs) which give rise to all blood cell lineages. Therefore, option A) HSC is the correct choice. The other cells listed— CFU-GM, CFU-G and CFU-GEMM—are intermediate progenitor cells that differentiate from HSCs and further proliferate and differentiate into specific blood cell types.

What Cell Appears to Be the Primary Site for the Defect