A patient presents with a moderate leukoerythroblastic anemia, striking anisocytosis and poikilocytosis.The anemia is normocytic, normochromic.Large platelets are noted.Dacryocytes, elliptocytes, and ovalocytes are present.Basophilic stippling is present.What disease is associated with these findings?

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Quizplus · Accepted Answer

The combination of moderate leukoerythroblastic anemia, striking anisocytosis and poikilocytosis, large platelets, basophilic stippling, and the presence of dacryocytes, elliptocytes, and ovalocytes are all indicative of a myeloproliferative neoplasm. However, the specific findings of dacryocytes and elliptocytes suggest the diagnosis of chronic idiopathic myelofibrosis (CIMF) specifically. The other myeloproliferative neoplasms, including chronic myeloid leukemia (CML), polycythemia vera (PV), and essential thrombocytosis (ET), may have some similar features, but not the exact combination seen in this patient.

A Patient Presents with a Moderate Leukoerythroblastic Anemia, Striking Anisocytosis