Question 1

How do hematologic disorders contribute to the pathogenesis of thrombocytopenia?

Accepted Answer

The answer of How do hematologic disorders contribute to the...

Question 2

A patient has a splitting headache shortly before getting her blood tested.She takes a couple of aspirin, and is scheduled for platelet aggregation studies.What effect will this have on the platelet aggregation studies?

Accepted Answer

Aspirin inhibits the function of platelet cyclooxygenase, a key enzyme in the platelet aggregation pathway. This leads to diminished activity in platelet aggregation studies with selected agonists.

Question 3

Which of the following contributes to the pathogenesis of Bernard-Soulier syndrome?

Accepted Answer

Bernard-Soulier syndrome is a rare genetic disorder that affects platelet function. It is caused by a deficiency or dysfunction of the glycoprotein Ib/IX complex, which is necessary for platelet adhesion to exposed collagen at the site of vessel injury. Abnormalities in the glycoprotein IIb/IIIa may lead to other platelet disorders, such as Glanzmann thrombasthenia. High platelet count and low fibrinogen levels, although they can be associated with bleeding disorders, are not specifically related to the pathogenesis of Bernard-Soulier syndrome.

Question 4

What laboratory tests are used to assess disorders of primary hemostasis? Secondary hemostasis?

Accepted Answer

The answer of What laboratory tests are used to assess...

Question 5

What is a common etiology of ITP in children?

Accepted Answer

ITP (Immune Thrombocytopenic Purpura) in children is often preceded by a viral infection, such as chickenpox. This leads to an immune response that mistakenly targets and destroys platelets, resulting in the symptoms of ITP.

Question 6

Which of the following characteristics differentiate chronic ITP from acute ITP?

Accepted Answer

Chronic ITP is more common in females, with a 3:1 female-to-male ratio.

Question 7

A patient is known to be a chronic alcoholic.His blood is drawn, and his platelet count is 72 x 10⁹/L.What is the most likely reason for this occurrence?

Accepted Answer

Chronic alcohol consumption can lead to bone marrow suppression, resulting in acquired hypoplasia and reduced platelet production, causing thrombocytopenia.

Question 8

Explain the pathophysiology of the following, and why each typically has normal coagulation screening tests.
A)Bernard-Soulier syndrome
B)Glanzmann's thrombasthenia
C)$\delta$-Storage pool disease
D)Gray platelet syndrome

Accepted Answer

The answer of Explain the pathophysiology of the following, and...

Question 9

Aspirin affects platelet aggregation because it interferes with:

Accepted Answer

Aspirin inhibits the activity of cyclooxygenase (COX) enzymes, which are involved in the synthesis of thromboxane A2, a potent mediator of platelet aggregation. Therefore, aspirin can decrease platelet aggregation by reducing thromboxane A2 production.

Question 10

What would be the expected laboratory results in a patient with thrombocytopenia?

Accepted Answer

Thrombocytopenia refers to a low platelet count, and platelet counts less than 50 x 10^9/L are common in this condition.

Answer: B
 Bleeding time may be prolonged in thrombocytopenia, as platelets play a crucial role in the formation of a clot to stop bleeding.

Answer: C
 PT and APTT (prothrombin time and activated partial thromboplastin time) are tests that assess different clotting factors in the blood. In thrombocytopenia, the PT and APTT may be normal or only mildly prolonged, as platelets are not directly involved in these pathways.

Answer: D
 Fibrinogen is a clotting factor produced by the liver, and its levels can be decreased in conditions that affect clotting, such as thrombocytopenia. However, this is not a consistent finding and fibrinogen levels may be within the normal range in some patients with thrombocytopenia.

Question 11

Immune complexes induce vasculitis by which of the following processes?

Accepted Answer

Immune complexes activate neutrophils to release enzymes and free oxygen radicals which cause tissue injury and inflammation leading to vasculitis. Inducing aggregation of platelets and activation factor XII (A) is involved in the process of blood coagulation and is not directly related to vasculitis. Increasing pressure within the lumen of capillaries (B) may cause capillary rupture, but it is not a direct mechanism of vasculitis. Formation of thrombi in small vessels, inducing necrosis (C) is a consequence of vasculitis and not the mechanism by which immune complexes induce vasculitis.

Question 12

Describe the following, and indicate where they are typically seen (disorders of primary hemostasis or secondary hemostasis).
A)Petechiae
B)Purpura
C)Ecchymoses
D)Hematomas

Accepted Answer

The answer of Describe the following, and indicate where they...

Question 13

What is the most common cause of thrombocytopenia?

Accepted Answer

Increased destruction of platelets is the most common cause of thrombocytopenia. This can occur due to autoimmune diseases, infections, medications, or other underlying conditions. Dilutional thrombocytopenia (A) can occur with blood transfusions, but is generally transient. Decreased production (C) can occur in bone marrow disorders or due to certain medications. Increased splenic sequestration (D) is a rare cause of thrombocytopenia and occurs when platelets are trapped in the spleen.

Quiz 30: Disorders of Primary Hemostasis

How do hematologic disorders contribute to the pathogenesis of thrombocytopenia?

A patient has a splitting headache shortly before getting her blood tested.She takes a couple of aspirin, and is scheduled for platelet aggregation studies.What effect will this have on the platelet aggregation studies?

Which of the following contributes to the pathogenesis of Bernard-Soulier syndrome?

What laboratory tests are used to assess disorders of primary hemostasis? Secondary hemostasis?

What is a common etiology of ITP in children?

Which of the following characteristics differentiate chronic ITP from acute ITP?

A patient is known to be a chronic alcoholic.His blood is drawn, and his platelet count is 72 x 10⁹/L.What is the most likely reason for this occurrence?

Explain the pathophysiology of the following, and why each typically has normal coagulation screening tests. A)Bernard-Soulier syndrome B)Glanzmann's thrombasthenia C) $\delta$ -Storage pool disease D)Gray platelet syndrome

Aspirin affects platelet aggregation because it interferes with:

What would be the expected laboratory results in a patient with thrombocytopenia?

Immune complexes induce vasculitis by which of the following processes?

Describe the following, and indicate where they are typically seen (disorders of primary hemostasis or secondary hemostasis). A)Petechiae B)Purpura C)Ecchymoses D)Hematomas

What is the most common cause of thrombocytopenia?

Quiz 30: Disorders of Primary Hemostasis

How do hematologic disorders contribute to the pathogenesis of thrombocytopenia?

A patient has a splitting headache shortly before getting her blood tested.She takes a couple of aspirin, and is scheduled for platelet aggregation studies.What effect will this have on the platelet aggregation studies?

Which of the following contributes to the pathogenesis of Bernard-Soulier syndrome?

What laboratory tests are used to assess disorders of primary hemostasis? Secondary hemostasis?

What is a common etiology of ITP in children?

Which of the following characteristics differentiate chronic ITP from acute ITP?

A patient is known to be a chronic alcoholic.His blood is drawn, and his platelet count is 72 x 109/L.What is the most likely reason for this occurrence?

Explain the pathophysiology of the following, and why each typically has normal coagulation screening tests. A)Bernard-Soulier syndrome B)Glanzmann's thrombasthenia C) δ\deltaδ -Storage pool disease D)Gray platelet syndrome

Aspirin affects platelet aggregation because it interferes with:

What would be the expected laboratory results in a patient with thrombocytopenia?

Immune complexes induce vasculitis by which of the following processes?

Describe the following, and indicate where they are typically seen (disorders of primary hemostasis or secondary hemostasis). A)Petechiae B)Purpura C)Ecchymoses D)Hematomas

What is the most common cause of thrombocytopenia?

A patient is known to be a chronic alcoholic.His blood is drawn, and his platelet count is 72 x 10⁹/L.What is the most likely reason for this occurrence?

Explain the pathophysiology of the following, and why each typically has normal coagulation screening tests. A)Bernard-Soulier syndrome B)Glanzmann's thrombasthenia C) $\delta$ -Storage pool disease D)Gray platelet syndrome