Using the PRP, platelet-rich plasma, in the aggregation studies of a patient's blood, the results were typical of the RIPA, ristocetin-induced platelet agglutination defect.The RIPA defect was corrected by adding normal plasma to the patient's PRP.In what disease is this seen?

Question

Quizplus · Accepted Answer

The RIPA defect, or ristocetin-induced platelet agglutination defect, is a characteristic feature of von Willebrand's disease. The correction of the defect by adding normal plasma also supports this diagnosis as von Willebrand factor is a protein found in plasma that is necessary for platelet function. Sticky platelet syndrome, Bernard-Soulier syndrome, and afibrinogenemia have different underlying mechanisms and would not be expected to show a correction of the RIPA defect by adding normal plasma.

Using the PRP, Platelet-Rich Plasma, in the Aggregation Studies of a Patient's