A hemophilic patient (Hemophilia A) has a severe bleed and is being treated with Factor VIII concentrate.When testing his post-infusion, the factor VIII level does not increase.The problem could be:

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Quizplus · Accepted Answer

The lack of increase in factor VIII level after infusion suggests the presence of a factor VIII inhibitor in the patient's blood. This is a common complication of treatment in hemophilic patients, as their immune systems can develop antibodies against the infused factor VIII concentrate. This inhibitor neutralizes the factor VIII and prevents its function, resulting in ineffective treatment of bleeding episodes. Lupus anticoagulant or improper drawing of the specimen would not affect the factor VIII level in this context, and the presence of a factor IX inhibitor is not relevant in Hemophilia A patients who lack this factor.

A Hemophilic Patient (Hemophilia A) Has a Severe Bleed and Is