How can the genetic mutation found with cystic fibrosis (CF) be characterized?
1) There are many variations in the mutation.
2) CF is the most common fatal childhood inherited disorder.
3) The mutation is a dominant trait.
4) The mutation stops ciliary function.

Question

Quizplus · Accepted Answer

1) Cystic fibrosis is caused by mutations in the CFTR gene, and there are over 1,700 different mutations identified that can cause the disease, showing a high degree of variation. 2) CF is indeed one of the most common fatal inherited disorders affecting children, particularly impacting the lungs and digestive system. The mutation is not a dominant trait but rather recessive, meaning both copies of the gene in each cell must have mutations for a person to have CF. The primary issue in CF is not stopped ciliary function but rather the production of thick, sticky mucus due to defective chloride transport across cell membranes, which can affect various organs including the lungs and pancreas.

How Can the Genetic Mutation Found with Cystic Fibrosis (CF)